Exhaled breath analysis has the potential to provide valuable insight on the status of various
metabolic pathways taking place in the lungs locally and other vital organs, via systemic …

Importance Continuous positive airway pressure (CPAP) and high-flow nasal oxygen
(HFNO) have been recommended for acute hypoxemic respiratory failure in patients with …

Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity and
mortality worldwide. In contrast to other chronic diseases, COPD is increasing in prevalence …

Background The ongoing coronavirus disease 2019 (COVID-19) pandemic has claimed
over two and a half million lives worldwide so far. Severe acute respiratory syndrome …

Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous
inflammatory airway disease. The epithelial-derived IL-33 and its receptor ST2 have been …

Acute cardiorespiratory breathlessness accounts for one in eight of all emergency
hospitalizations. Early, noninvasive diagnostic testing is a clinical priority that allows rapid …

Precision medicine has spurred new innovations in molecular pathology leading to recent
advances in the analysis of exhaled breath as a non-invasive diagnostic tool. Volatile …

Comprehensive two-dimensional gas chromatography (GC× GC) is a powerful analytical
tool for both nontargeted and targeted analyses. However, there is a need for more …

Background Asthma and COPD continue to cause considerable diagnostic and treatment
stratification challenges. Volatile organic compounds (VOCs) have been proposed as …

Introduction Patients presenting with acute undifferentiated breathlessness are commonly
encountered in admissions units across the UK. Existing blood biomarkers have clinical …