Transgenic plants expressing insecticidal proteins from the bacterium Bacillus thuringiensis
(Bt) were first commercialized in 1996 amid concern from some scientists, regulators and …

Starting with the launch of the Human Genome Project three decades ago, and continuing
after its completion in 2003, genomics has progressively come to have a central and …

The adipose-derived hormone leptin regulates energy balance and neuroendocrine
function, and resistance to its appetite-suppressing effects might underlie common forms of …

Many architects believe that major improvements in cost-energy-performance must now
come from domain-specific hardware. This paper evaluates a custom ASIC---called a Tensor …

The adipocyte-derived hormone leptin signals the status of body energy stores by activating
the long form of the leptin receptor (LRb). Activation of LRb results in the activation of the …

Secretion of leptin from adipocytes communicates body energy status to the brain by
activating the leptin receptor long form (LRb). LRb regulates energy homeostasis and …

During leptin signaling, each of the phosphorylated tyrosine residues on the long form of the
leptin receptor (LRb) mediates distinct signals. Phosphorylated Tyr 1138 binds STAT3 to …

The protein tyrosine phosphatase SHP-2 has been proposed to serve as a regulator of leptin
signaling, but its specific roles are not fully examined. To directly investigate the role of SHP …

D‐pinitol (3‐O‐methyl‐chiroinositol), an active principle of the traditional antidiabetic plant
Bougainvillea spectabilis, is claimed to exert insulin‐like effects. This study investigates the …

Background Discoveries that emerging and re-emerging pathogens have their origin in
environmental change has created an urgent need to understand how these environmental …