Metformin is widely used in the treatment of diabetes mellitus type 2 where it reduces insulin
resistance and diabetes-related morbidity and mortality. Population-based studies show that …

Physiological Approach to Assessment of Acid–Base Disturbances | NEJM Skip to main content
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BACKGROUND: Channelopathies, defined as diseases that are caused by mutations in
genes encoding ion channels, are associated with a wide variety of symptoms and have …

Background—For the general population, the clinical relevance of an increased urinary
albumin excretion rate is still debated. Therefore, we examined the relationship between …

Context: Thyroid disease and the metabolic syndrome are both associated with
cardiovascular disease. Objective: The aim of this study was to explore the hypothesis that …

OBJECTIVE Several studies have suggested an association between specific diabetes
treatment and cancer mortality. We studied the association between metformin use and …

Tissue advanced glycation end products (AGE) are a measure of cumulative metabolic
stress and trigger cytokines driven inflammatory reactions. AGE are thought to contribute to …

OBJECTIVE—Advanced glycation end products (AGEs) are biomarkers of metabolic stress
and are thought to contribute to the increase of coronary heart disease (CHD) in diabetes …

OBJECTIVE—Advanced glycation end products (AGEs) are thought to have a role in the
pathogenesis of diabetes complications. We recently reported the association between skin …

Objectives: In this study we considered the question of whether adjunction of glucose-insulin-
potassium (GIK) infusion to primary coronary transluminal angioplasty (PTCA) is effective in …