Metformin is quite frequently used off-label in type 1 diabetes to limit insulin dose
requirement. Guidelines recommend that it can improve glucose control in those who are …

Type 2 diabetes (T2D) carries risks of both cardiovascular (CV)(myocardial infarction, stroke,
and peripheral vascular disease) and microvascular (retinopathy/nephropathy/neuropathy) …

Trafficking within eukaryotic cells is a complex and highly regulated process; events such as
recycling of plasma membrane receptors, formation of multivesicular bodies, regulated …

Introduction The regulated delivery of the glucose transporter GLUT4 from intracellular
stores to the plasma membrane underpins insulin‐stimulated glucose transport. Insulin …

Adipocytes are key to metabolic regulation, exhibiting insulin-stimulated glucose transport
that is underpinned by the insulin-stimulated delivery of glucose transporter type 4 (SLC2A4 …

A major consequence of insulin binding its receptor on fat and muscle cells is the stimulation
of glucose transport into these tissues. This is achieved through an increase in the exocytic …

Five species of sea turtle are known to nest on the north and east coast beaches of Trinidad,
West Indies. In descending order of abundance: the leatherback (Dermochelys coriacea) …

Diabetes is becoming more prevalent in the UK and this is represented in the in-patient
cohort, such that 1 in 6 hospital patients have diabetes (1). The UK National Diabetes In …

SGLT2 inhibitors have been shown to have benefits on glycaemic control, as well as on
cardiovascular risk factors including weight loss, blood pressure reduction and some effects …

The pest population of H. vigintioctopunctata varies from region to region based on their
climatic conditions and shows different peak activity in different locations. The present study …