New advances in the second-line treatment of small cell lung cancer

JL Hurwitz, F McCoy, P Scullin, DA Fennell - The oncologist, 2009 - academic.oup.com
Lung cancer is the leading cause of cancer-related death in the UK, with small cell histology
accounting for 15%–20% of cases. Small cell lung cancer (SCLC) is initially a …

HIF-1 and NF-κB-mediated upregulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells

PJ Maxwell, R Gallagher, A Seaton, C Wilson, P Scullin… - Oncogene, 2007 - nature.com
Hypoxic cancer cells are resistant to treatment, leading to the selection of cells with a more
malignant phenotype. The expression of interleukin-8 (IL-8) plays an important role in the …

Interleukin-8 signaling promotes androgen-independent proliferation of prostate cancer cells via induction of androgen receptor expression and activation

A Seaton, P Scullin, PJ Maxwell, C Wilson… - …, 2008 - academic.oup.com
The aim of our study was to assess the importance of the CXC chemokine and interleukin
(IL)-8 in promoting the transition of prostate cancer (CaP) to the androgen-independent …

[HTML][HTML] Response to chemotherapy is predictive in relation to longer overall survival in an individual patient combined-analysis with pleural mesothelioma

JK Blayney, GL Ceresoli, B Castagneto… - European journal of …, 2012 - Elsevier
BACKGROUND: There is currently no early predictive marker of survival for patients
receiving chemotherapy for malignant pleural mesothelioma (MPM). Tumour response may …

[HTML][HTML] Dexamethasone potentiates the antiangiogenic activity of docetaxel in castration-resistant prostate cancer

C Wilson, P Scullin, J Worthington, A Seaton… - British journal of …, 2008 - nature.com
We sought to characterise whether dexamethasone (DEX) may enhance tumour response to
docetaxel in in vitro and in vivo models of metastatic prostate cancer (CaP). In vitro …

[HTML][HTML] Phase II study of gemcitabine and cisplatin in locally advanced/metastatic oesophageal cancer

J Millar, P Scullin, A Morrison, B McClory, L Wall… - British journal of …, 2005 - nature.com
Palliative chemotherapy for inoperable/metastatic oesophageal cancer has limited activity.
This study assesses the feasibility and activity of gemcitabine and cisplatin in this group of …

Chasing the Golden Hour–Lessons learned from improving initial neutropenic sepsis management.

C Forde, P Scullin - BMJ Open Quality, 2017 - bmjopenquality.bmj.com
Neutropenic sepsis remains a time critical and potentially fatal complication of systemic anti-
cancer therapy. A target 'door to needle'time of one hour for first dose empirical intravenous …

Afatinib treatment in advanced non-small cell lung cancer

JL Hurwitz, P Scullin, L Campbell - Lung Cancer: Targets and …, 2011 - Taylor & Francis
Despite some recent advances in the management of advanced non-small cell lung cancer
(NSCLC), prognosis for these patients remains poor. Small molecule epidermal growth …

Myoclonic jerks associated with gabapentin

P Scullin, P Sheahan, S Kelly - Palliative medicine, 2003 - journals.sagepub.com
Myoclonic jerks associated with gabapentin - Paula Scullin, Patricia Sheahan, Sheila Kelly,
2003 Skip to main content Intended for healthcare professionals Sage Journals Home Search …

[HTML][HTML] Improving the safety of chemotherapy prescribing in oncology through the introduction of an assessment proforma

P Scullin, O Devlin, C Forde - BMJ Open Quality, 2017 - bmjopenquality.bmj.com
Chemotherapy remains a high risk treatment with the potential to cause significant patient
morbidity and mortality. In the UK the Manual for Cancer Services: Chemotherapy Measures …