[PDF][PDF] Immunology of COVID-19: current state of the science
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting …
syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting …
Macrophages in health and disease
The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …
increasingly transparent over the last decade. But with the plethora of data comes a natural …
Macrophages: a Trojan horse in COVID-19?
MD Park - Nature reviews immunology, 2020 - nature.com
There is rising concern that patients who recover from COVID-19 may be at risk of
reinfection. In this preprint, Bao et al. investigated acquired immunity to SARS-CoV-2 in …
reinfection. In this preprint, Bao et al. investigated acquired immunity to SARS-CoV-2 in …
Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells
M Casanova-Acebes, E Dalla, AM Leader, J LeBerichel… - Nature, 2021 - nature.com
Macrophages have a key role in shaping the tumour microenvironment (TME), tumour
immunity and response to immunotherapy, which makes them an important target for cancer …
immunity and response to immunotherapy, which makes them an important target for cancer …
Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma
Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T
cell rich tumors fail to respond to immune checkpoint blockade (ICB). We leveraged a …
cell rich tumors fail to respond to immune checkpoint blockade (ICB). We leveraged a …
[PDF][PDF] Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification
Immunotherapy is a mainstay of non-small cell lung cancer (NSCLC) management. While
tumor mutational burden (TMB) correlates with response to immunotherapy, little is known …
tumor mutational burden (TMB) correlates with response to immunotherapy, little is known …
TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer
MD Park, I Reyes-Torres, J LeBerichel, P Hamon… - Nature …, 2023 - nature.com
Natural killer (NK) cells are commonly reduced in human tumors, enabling many to evade
surveillance. Here, we sought to identify cues that alter NK cell activity in tumors. We found …
surveillance. Here, we sought to identify cues that alter NK cell activity in tumors. We found …
A 78 dB SNDR 87 mW 20 MHz Bandwidth Continuous-Time ADC With VCO-Based Integrator and Quantizer Implemented in 0.13 m CMOS
M Park, MH Perrott - IEEE Journal of Solid-State Circuits, 2009 - ieeexplore.ieee.org
The use of a VCO-based integrator and quantizer within a continuous-time (CT) ΔΣ analog-
to-digital converter (ADC) structure is explored, and a custom prototype in a 0.13 μm CMOS …
to-digital converter (ADC) structure is explored, and a custom prototype in a 0.13 μm CMOS …
Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling
RL Rabin, MK Park, F Liao, R Swofford… - The Journal of …, 1999 - journals.aai.org
To address the issues of redundancy and specificity of chemokines and their receptors in
lymphocyte biology, we investigated the expression of CC chemokine receptors CCR1 …
lymphocyte biology, we investigated the expression of CC chemokine receptors CCR1 …
Oxygen tensions and infections: modulation of microbial growth, activity of antimicrobial agents, and immunologic responses
MK Park, RAM Myers, L Marzella - Clinical infectious diseases, 1992 - academic.oup.com
Oxygen tensions play an important role in the outcome of infections. Oxygen is cidal or static
for microorganisms that lack defenses against oxidants. Hyperoxia and hyperbaric oxygen …
for microorganisms that lack defenses against oxidants. Hyperoxia and hyperbaric oxygen …