Rituximab is a chimeric monoclonal antibody used to treat hematologic and autoimmune
diseases by depleting CD20-expressing B cells. Patients may develop …

Granulomas have been defined as inflammatory infiltrates formed by recruitment of
macrophages and T cells. The three-dimensional spherical structure typically consists of a …

The pathophysiology of pediatric sepsis is characterized by increased innate immune
activation earlier in life. Interleukin-1 is a proinflammatory cytokine implicated in the …

Background More than 95% of humans have been infected with Epstein–Barr virus (EBV)
and develop anti-EBV IgG antibodies, conferring immunity. However, among specific …

Highlights•Primary Atopic Disorders are monogenic causes of allergic symptoms leading to
a wide variety of phenotypes.•Many of these individual disorders vary in the presence, type …

Background Penicillin allergy is the most commonly reported drug allergy in hospitalized
patients, resulting in increased second-line antibiotic use, nosocomial infections, and health …

Antibody responses to pneumococcal polysaccharide vaccination are frequently used as a
diagnostic tool for humoral immunodeficiencies, part of the larger collection of inborn errors …

The blood volume cultured in the detection of bacteraemia is a major variable in treating
patients with systemic inflammatory response syndrome. The fact that drawing optimal …

Purpose Chronic granulomatous disease (CGD) is an innate immune deficiency, primarily
affecting the phagocytic compartment, and presenting with a diverse phenotypic spectrum …

Background: A history of penicillin allergy is associated with an increased risk of nosocomial
infections because patients are exposed to non-beta lactam antibiotics. Ruling out …