Beyond the laboratory: clinical implications for statin pleiotropy

JPJ Halcox, JE Deanfield - Circulation, 2004 - Am Heart Assoc
Results from large-scale clinical trials of lipid lowering with 3-hydroxy-3-methylglutaryl-
coenzyme A (HMG-CoA) reductase inhibitors (statins) have led to a revolution in the …

[HTML][HTML] Circulating endothelial progenitor cells, vascular function, and cardiovascular risk

JM Hill, G Zalos, JPJ Halcox… - … England Journal of …, 2003 - Mass Medical Soc
Background Cardiovascular risk factors contribute to atherogenesis by inducing endothelial-
cell injury and dysfunction. We hypothesized that endothelial progenitor cells derived from …

Prognostic value of coronary vascular endothelial dysfunction

JPJ Halcox, WH Schenke, G Zalos, R Mincemoyer… - Circulation, 2002 - Am Heart Assoc
Background—Whether patients at increased risk can be identified from a relatively low-risk
population by coronary vascular function testing remains unknown. We investigated the …

Glucagon‐like peptide‐1 receptor agonists improve biomarkers of inflammation and oxidative stress: a systematic review and meta‐analysis of randomised controlled …

JJH Bray, H Foster‐Davies, A Salem… - Diabetes, Obesity …, 2021 - Wiley Online Library
Aim To conduct a meta‐analysis and systematic review to examine the effects of glucagon‐
like peptide‐1 receptor agonists (GLP‐1RAs) on clinical biomarkers of inflammation and …

Assessment of remote heart rhythm sampling using the AliveCor heart monitor to screen for atrial fibrillation: the REHEARSE-AF study

JPJ Halcox, K Wareham, A Cardew, M Gilmore… - Circulation, 2017 - Am Heart Assoc
Background: Asymptomatic atrial fibrillation (AF) is increasingly common in the aging
population and implicated in many ischemic strokes. Earlier identification of AF with …

Endothelial function predicts progression of carotid intima-media thickness

JPJ Halcox, AE Donald, E Ellins, DR Witte, MJ Shipley… - Circulation, 2009 - Am Heart Assoc
Background—Endothelial dysfunction develops early and has been shown to predict the
development of clinical complications of atherosclerosis. However, the relationship between …

Predisposition to atherosclerosis by infections: role of endothelial dysfunction

A Prasad, J Zhu, JPJ Halcox, MA Waclawiw… - Circulation, 2002 - Am Heart Assoc
Background—Several microorganisms have been implicated in the pathogenesis of
atherosclerosis. We hypothesized that infections may predispose to atherosclerosis by …

The effect of sildenafil on human vascular function, platelet activation, and myocardial ischemia

JPJ Halcox, KRA Nour, G Zalos, R Mincemoyer… - Journal of the American …, 2002 - jacc.org
Objectives: We studied the effects of sildenafil, a phosphodiesterase 5 inhibitor, on coronary
and peripheral vascular function, platelet activation, and myocardial ischemia. Background …

Association between polymorphism in the chemokine receptor CX3CR1 and coronary vascular endothelial dysfunction and atherosclerosis

DH McDermott, JPJ Halcox, WH Schenke… - Circulation …, 2001 - Am Heart Assoc
Fractalkine, a chemokine expressed by inflamed endothelium, induces leukocyte adhesion
and migration via the receptor CX3CR1, and the CX3CR1 polymorphism V249I affects …

Vasculopathy in Turner syndrome: arterial dilatation and intimal thickening without endothelial dysfunction

JE Ostberg, AE Donald, JPJ Halcox… - The Journal of …, 2005 - academic.oup.com
Abstract Context: Women with Turner syndrome (TS) have an increased cardiovascular
mortality rate from both structural and ischemic heart disease, especially aortic dissection …