Objective.—To examine whether cholesterol lowering with 3-hydroxy-3-methylglutaryl
coenzyme A (HMG-CoA) reductase inhibitors (statin drugs) reduces the risks of stroke and …

Elevated plasma homocysteine levels have been associated with higher risks of
cardiovascular disease, but the effects on disease rates of supplementation with folic acid to …

PURPOSE: To assess the balance of benefits and risks of supplementation with beta-
carotene, vitamin E, vitamin C, and multivitamins on cancer, cardiovascular (CVD), and eye …

Context Secondary analyses of 2 randomized controlled trials and supportive epidemiologic
and preclinical data indicated the potential of selenium and vitamin E for preventing prostate …

Context The initial report of the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
found no reduction in risk of prostate cancer with either selenium or vitamin E supplements …

Background Observational studies suggest that people who consume more fruits and
vegetables containing beta carotene have somewhat lower risks of cancer and …

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular
disease. We report the largest genetic association study of blood pressure traits (systolic …

Background Randomized trials have shown that low-dose aspirin decreases the risk of a first
myocardial infarction in men, with little effect on the risk of ischemic stroke. There are few …

Background It has been hypothesized that the pathogenesis of diseases induced by
cigarette smoking involves oxidative damage by free radicals. However, definitive evidence …

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-
wide association studies, we observed large chromosomal abnormalities in a subset of …