Abstract The latest French Guidelines for the management in the first 24 hours of patients
with severe traumatic brain injury (TBI) were published in 1998. Due to recent changes …

Opioid-free anesthesia (OFA) is used in surgery to avoid opioid-related side effects.
However, uncertainty exists in the balance between OFA benefits and risks. We searched for …

The influenza H1N1 epidemics in 2009 led a substantial number of people to develop
severe acute respiratory distress syndrome and refractory hypoxemia. In these patients …

Background Rapid development of acute opioid tolerance is well established in animals and
is more likely to occur with large doses of short-acting drugs. The authors therefore tested …

Background Remifentanil-induced secondary hyperalgesia has been documented
experimentally in both animals and healthy human volunteers, but never clinically. This …

In order to examine whether changes in the bispectral index (BIS) may be an adequate
monitor for the analgesic component of anesthesia, we evaluated the effect of remifentanil …

BACKGROUND Chronic postsurgical pain (CPSP) is an important clinical problem.
Prospective studies of the incidence, characteristics and risk factors of CPSP are needed …

In a randomized, double-blinded study with three parallel groups, we assessed the
analgesic effect of intraoperative ketamine administration in 45 ASA physical status I or II …

We carried out a national survey on postoperative pain (POP) management in a
representative sample (public/private, teaching/non-teaching, size) of 76 surgical centers in …

Poor management of post-operative acute pain can contribute to medical complications
including pneumonia, deep vein thrombosis, infection and delayed healing, as well as the …