This report summarizes the results of a multinational pharmaceutical company survey and
the outcome of an International Life Sciences Institute (ILSI) Workshop (April 1999), which …

The science behind the use of uncertainty factors has progressed considerably. Increased
knowledge of inter-and intraspecies sensitivity, mechanisms of action, and detailed …

Administered a child development questionnaire, a parent opinion questionnaire, and a
parent problem-solving instrument to 10 abusing mothers, 10 neglectful mothers, and 10 …

Risk assessment methodology, particularly pertaining to potential human carcinogenic risks
from exposures to environmental chemicals, is undergoing intense scrutiny from scientists …

The purpose of the workshop “Do Peroxisome Proliferating Compounds Pose a
Hepatocarcinogenic Hazard to Humans?” was to provide a review of the current state of the …

Objectives To examine the effects of food ingestion and administered dose on the
absorption of oral micronized P (Utrogestan; Besins-Iscovesco, Paris, France) and to …

This project was undertaken by the International Life Sciences Institute's Health and
Environmental Sciences Institute (ILSI-HESI) to develop an improved understanding of the …

The willingness of the agencies involved in the regulation of pharmaceuticals to accept data
from newly proposed models for carcinogenicity testing (eg, transgenic animals, neonatal …

Advances in genetic engineering have created opportunities for improved understanding of
the molecular basis of carcinogenesis. Through selective introduction, activation, and …

Physiologically based pharmacokinetic (PBPK) models have been developed describing the
disposition kinetics of nicotine and its major metabolite, cotinine, in man. Separate 9 …