Building the invisible wall: updating the chlamydial peptidoglycan anomaly

AJ McCoy, AT Maurelli - TRENDS in Microbiology, 2006 - cell.com
The existence of peptidoglycan (PG) in chlamydiae has long been debated. Genome
sequencing of members of the Chlamydiaceae family and Protochlamydia amoebophila has …

[HTML][HTML] Prediction of respiratory decompensation in Covid-19 patients using machine learning: The READY trial

H Burdick, C Lam, S Mataraso, A Siefkas… - Computers in biology …, 2020 - Elsevier
Background Currently, physicians are limited in their ability to provide an accurate prognosis
for COVID-19 positive patients. Existing scoring systems have been ineffective for identifying …

Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-κB signaling

C Toma, N Higa, Y Koizumi, N Nakasone… - The Journal of …, 2010 - journals.aai.org
Vibrio vulnificus and Vibrio cholerae are Gram-negative pathogens that cause serious
infectious disease in humans. The β form of pro–IL-1 is thought to be involved in …

[HTML][HTML] DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity

I Chuang, M Sedegah, S Cicatelli, M Spring… - PloS one, 2013 - journals.plos.org
Background Gene-based vaccination using prime/boost regimens protects animals and
humans against malaria, inducing cell-mediated responses that in animal models target liver …

Reducing patient mortality, length of stay and readmissions through machine learning-based sepsis prediction in the emergency department, intensive care unit and …

A McCoy, R Das - BMJ open quality, 2017 - bmjopenquality.bmj.com
Introduction Sepsis management is a challenge for hospitals nationwide, as severe sepsis
carries high mortality rates and costs the US healthcare system billions of dollars each year …

Identification of Proteus mirabilisMutants with Increased Sensitivity to Antimicrobial Peptides

AJ McCoy, H Liu, TJ Falla, JS Gunn - Antimicrobial agents and …, 2001 - Am Soc Microbiol
Antimicrobial peptides (APs) are important components of the innate defenses of animals,
plants, and microorganisms. However, some bacterial pathogens are resistant to the action …

l,l-diaminopimelate aminotransferase, a trans-kingdom enzyme shared by Chlamydia and plants for synthesis of diaminopimelate/lysine

AJ McCoy, NE Adams, AO Hudson… - Proceedings of the …, 2006 - National Acad Sciences
The synthesis of meso-diaminopimelic acid (m-DAP) in bacteria is essential for both
peptidoglycan and lysine biosynthesis. From genome sequencing data, it was unclear how …

[HTML][HTML] Mortality prediction model for the triage of COVID-19, pneumonia, and mechanically ventilated ICU patients: A retrospective study

L Ryan, C Lam, S Mataraso, A Allen… - Annals of Medicine and …, 2020 - Elsevier
Rationale Prediction of patients at risk for mortality can help triage patients and assist in
resource allocation. Objectives Develop and evaluate a machine learning-based algorithm …

In Vitro and In Vivo Functional Activity of Chlamydia MurA, a UDP-N-Acetylglucosamine Enolpyruvyl Transferase Involved in Peptidoglycan Synthesis and …

AJ McCoy, RC Sandlin, AT Maurelli - Journal of bacteriology, 2003 - Am Soc Microbiol
Organisms of Chlamydia spp. are obligate intracellular, gram-negative bacteria with a
dimorphic developmental cycle that takes place entirely within a membrane-bound vacuole …

Campylobacter jejuni transcriptional and genetic adaptation during human infection

AA Crofts, FM Poly, CP Ewing, JM Kuroiwa… - Nature …, 2018 - nature.com
Campylobacter jejuni infections are a leading cause of bacterial food-borne diarrhoeal
illness worldwide, and Campylobacter infections in children are associated with stunted …