Major Article
Skin reactions related to hand hygiene and selection of hand hygiene products

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Background

In October 2004, The World Health Organization (WHO) launched the World Alliance for Patient Safety. Within the alliance, the first priority of the Global Patient Safety Challenge is to reduce health care-associated infection. A key action within the challenge is to promote hand hygiene in health care globally as well as at the country level through the campaign “Clean Care is Safer Care.” As a result, the WHO is developing Guidelines on Hand Hygiene in Health Care, designed to be applicable throughout the world.

Methods

This paper summarizes one component of the global WHO guidelines related to the impact of hand hygiene on the skin of health care personnel, including a discussion of types of skin reactions associated with hand hygiene, methods to reduce adverse reactions, and factors to consider when selecting hand hygiene products.

Results

Health care professionals have a higher prevalence of skin irritation than seen in the general population because of the necessity for frequent hand hygiene during patient care.

Conclusion

Ways to minimize adverse effects of hand hygiene include selecting less irritating products, using skin moisturizers, and modifying certain hand hygiene practices such as unnecessary washing. Institutions need to consider several factors when selecting hand hygiene products: dermal tolerance and aesthetic preferences of users as well as practical considerations such as convenience, storage, and costs.

Section snippets

Skin reactions related to hand hygiene

There are 2 major types of skin reactions associated with hand hygiene. The first and most common is irritant contact dermatitis with symptoms that include dryness, irritation, itching, cracking, and bleeding. The second, allergic contact dermatitis, is rare and results from an allergy to an ingredient in the hand hygiene product. Symptoms of allergic contact dermatitis can be mild and localized or severe and generalized. In the most serious form, there may be respiratory distress and other

Methods to reduce adverse effects of agents

There are 3 primary strategies for minimizing hand hygiene-related irritant contact dermatitis among health care personnel: selection of less irritating hand hygiene products; education regarding proper skin care management, and routine use of moisturizing skin care products.

Factors to consider when selecting hand hygiene products

The selection of hand hygiene agents requires a multidisciplinary team effort (eg, infection control professionals, both clinical and administrative staff, pharmacists, behavioral scientists) to evaluate factors related to handcleansing agents and to conduct clinical pilot projects to test these factors.20, 54, 76, 77, 78, 79 Therefore, pilot studies to help select products at the local level should mainly address user acceptability issues. Other aspects such as tolerance, availability,

Summary and recommendations

Because of the necessity for frequent hand hygiene during patient care, health care professionals have a higher prevalence of skin irritation than seen in the general population. Damaged, irritated skin is undesirable, not only because it causes discomfort and even lost workdays for the professional but also because hands with damaged skin may in fact increase the risk of transmission of infections to patients. Ways to minimize the possible adverse effects of hand hygiene include selecting less

References (112)

  • E.L. Larson et al.

    Changes in bacterial flora associated with skin damage on hands of health care personnel

    Am J Infect Control

    (1998)
  • J. Cimiotti et al.

    Adverse reactions associated with an alcohol-based hand antiseptic among nurses in a neonatal intensive care unit

    Am J Infect Control

    (2003)
  • D. Scott et al.

    An evaluation of the user acceptability of chlorhexidine handwash formulations

    J Hosp Infect

    (1991)
  • P. Turner et al.

    Dermal absorption of isopropyl alcohol from a commercial hand rub: implications for its use in hand decontamination

    J Hosp Infect

    (2004)
  • G.A.J. Ayliffe et al.

    Hand disinfection: a comparison of various agents in laboratory and ward studies

    J Hosp Infect

    (1988)
  • J.L. Newman et al.

    Intermittent use of an antimicrobial hand gel for reducing soap-induced irritation of health care personnel

    Am J Infect Control

    (1990)
  • T. Brick et al.

    Water contamination in urban south India: household storage practices and their implications for water safety and enteric infections

    Int J Hyg Environ Health

    (2004)
  • B. Sultana et al.

    Effects of age and race on skin condition and bacterial counts on hands of neonatal ICU nurses

    Heart Lung

    (2003)
  • D.R. Smith et al.

    Hand dermatitis among nurses in a newly developing region of Mainland China

    Int J Nurs Studies

    (2005)
  • R.D. McCormick et al.

    Double-blind, randomized trial of scheduled use of a novel barrier cream and an oil-containing lotion for protecting the hands of health care workers

    Am J Infect Control

    (2000)
  • E. Held et al.

    The combined use of moisturizers and occlusive gloves: an experimental study

    Am J Contact Dermatol

    (1999)
  • D.P. West et al.

    Evaluation of aloe vera gel gloves in the treatment of dry skin associated with occupational exposure

    Am J Infect Control

    (2003)
  • E.L. Larson

    APIC guideline for handwashing and hand antisepsis in health care settings

    Am J Control

    (1995)
  • E. Larson et al.

    Effects of a protective foam on scrubbing and gloving

    Am J Infect Control

    (1993)
  • A.P. Fraise

    Choosing disinfectants

    J Hosp Infect

    (1999)
  • C. Wendt

    Hand hygiene—comparison of international recommendations

    J Hosp Infect

    (2001)
  • M.L. Rotter et al.

    The influence of cosmetic additives on the acceptability of alcohol- based hand disinfectants

    J Hosp Infect

    (1991)
  • A. Kramer et al.

    Clinical double-blind trial on the dermal tolerance and user acceptability of six alcohol-based hand disinfectants for hygienic hand disinfection

    J Hosp Infect

    (2002)
  • G. Kampf et al.

    Dermal tolerance and effect on skin hydration of a new ethanol-based hand gel

    J Hosp Infect

    (2002)
  • G. Kampf et al.

    Dermal tolerance of Sterillium, a propanol-based hand rub

    J Hosp Infect

    (2003)
  • A. Kramer et al.

    Limited efficacy of alcohol-based hand gels

    Lancet

    (2002)
  • R. Wurtz et al.

    Handwashing machines, handwashing compliance, and potential for cross-contamination

    Am J Infect Control

    (1994)
  • D. Pittet

    Compliance with hand disinfection and its impact on hospital-acquired infections

    J Hosp Infect

    (2001)
  • G.E. Bignardi

    An obstacle too many

    J Hosp Infect

    (2002)
  • J.A. Mayer et al.

    Increasing handwashing in an intensive care unit

    Infect Control

    (1986)
  • J.J. Parienti et al.

    Hand-rubbing with an aqueous alcoholic solution vs. traditional surgical hand-scrubbing and 30-day surgical site infection rates

    JAMA

    (2002)
  • D. Pittet

    Improving compliance with hand hygiene in hospitals

    Infect Control Hosp Epidemiol

    (2000)
  • Tupker RA. Detergent and cleansers. In: van der Valk PGMM, HI, editors. The irritant contact dermatitis syndrome. New...
  • M. Graham et al.

    Low rates of cutaneous adverse reactions to alcohol-based hand hygiene solution during prolonged use in a large teaching hospital

    Antimicrob Agents Chemother

    (2005)
  • K.-P. Wilhelm

    Prevention of surfactant-induced irritant contact dermatitis

  • J. Ojajarvi et al.

    Failure of hand disinfection with frequent hand washing: a need for prolonged field studies

    J Hyg (London)

    (1977)
  • M. Winnefeld et al.

    Skin tolerance and effectiveness of two hand decontamination procedures in everyday hospital use

    Br J Dermatol

    (2000)
  • M. Rotter

    Hand washing and hand disinfection

  • P. de Haan et al.

    Irritancy of alcohols

  • E. Larson et al.

    Physiologic and microbiologic changes in skin related to frequent handwashing

    Infect Control

    (1986)
  • J. Lubbe et al.

    Irritancy of the skin disinfectant n-propanol

    Contact Dermatitis

    (2001)
  • J. Ohlenschlaeger et al.

    Temperature dependency of skin susceptibility to water and detergents

    Acta dermato-venereologica

    (1996)
  • A. Emilson et al.

    The temperature effect of in vitro penetration of sodium lauryl sulfate and nickel chloride through human skin

    Acta Dermato-venereologica

    (1993)
  • A.C. De Groot

    Contact allergy to cosmetics: causative ingredients

    Contact Dermatitis

    (1987)
  • A. Schnuch et al.

    Contact allergies in health care workers—results from the IVDK

    Acta Dermato-venereologica

    (1998)
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    On behalf of the World Health Organization Global Patient Safety Challenge (Lead, Professor D. Pittet, World Alliance for Patient Safety, WHO Headquarters, Geneva, Switzerland).

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