Table 3

Adjusted associations between DNR within 24 hours and ICH care processes

Care process outcomeModel typeEstimate for DNR <24 hours95% CIP valueAdditional model variables
Door-to-needle time anticoagulant reversal (hour)Linear regression0.49−0.58 to 1.560.365
Door-to-target time BP lowering (hour)Log-linear regression−0.22−0.52 to 0.080.146Age, ICH Volume, IVH, ICH Location, GCS, Systolic BP on admission
Door-to-first enteral hypertensive time (hour)Log-linear regression0.18−0.07 to 0.430.147Age, ICH Volume, IVH, ICH Location, GCS
Admission to critical care in first 72 hoursLogistic regression0.070.03 to 0.17<0.001Age, ICH Volume, IVH, ICH Location, GCS, pre-ICH mRS
Repeat scan within 6 hours of ENDLogistic regression0.610.27 to 1.350.222Age, ICH Volume, IVH, ICH Location, GCS, pre-ICH mRS
Commencement of palliative care <72 hoursLogistic regression8.764.74 to 16.61<0.001Age, ICH Volume, IVH, ICH Location, GCS, pre-ICH mRS
  • All models adjusted for onset to arrival and implementation group (before, during or after). Additional variables that were adjusted for are detailed. All variables were chosen clinically.

  • P values ‹ 0.05 are shown in bold.

  • BP, blood pressure; DNR, do-not-resuscitate; END, early neurological decline; GCS, Glasgow Coma Scale; ICH, intracerebral haemorrhage; IVH, intraventricular haemorrhage; mRS, modified Rankin Scale.