Meta-regression of single DTN reduction strategies within Combination Interventions against standard mean difference of door-to-needle time reduction
| Variable | Coefficient | SE | t | p>|t| | 95% CI |
| Prehospital Notification | 1.694 | 0.952 | 1.78 | 0.085 | −0.248 to 3.637 |
| Stroke Tools | 1.206 | 0.978 | 1.23 | 0.227 | −0.788 to 3.201 |
| Rapid Triage and Stroke Team Notification | 0.985 | 0.958 | 1.03 | 0.312 | −0.97 to 2.94 |
| Single Call Activation System | −0.559 | 1.542 | −0.36 | 0.72 | −3.706 to 2.587 |
| Transfer Directly to CT/MRI | −0.76 | 1.154 | −0.66 | 0.515 | −3.114 to 1.594 |
| Rapid Acquisition and Interpretation of Brain Imaging | −0.096 | 1.233 | −0.08 | 0.938 | −2.611 to 2.419 |
| Rapid Lab Testing (including PoC) | 0.423 | 1.201 | 0.35 | 0.727 | −2.026 to 2.873 |
| Mixed tPA Ahead of Time | 1.824 | 1.413 | 1.29 | 0.206 | −1.056 to 4.706 |
| Rapid Access and Administration of tPA | 0.597 | 1.059 | 0.56 | 0.577 | −1.563 to 2.757 |
| Team-Based Approach | −0.387 | 0.983 | −0.39 | 0.696 | −2.392 to 1.617 |
| Prompt Data Feedback | 0.174 | 1.135 | 0.15 | 0.879 | −2.14 to 2.489 |
| Non-Target Interventions | 2.362 | 0.966 | 2.44 | 0.02 | 0.391 to 4.332 |
DTN, door-to-needle time; tPA, tissue plasminogen activator.