Table 1

Summary of findings

Baseline
(May 2015 to
October 2016)
Period 1
(November 2016 to March 2017)
Period 2
(April 2017 to December 2017)
VAE rate* (per 1000 ventilator days)6.84.31.3
VAE rate* (per 100 ventilated patients)5.23.30.7
Primary outcomes
 Mean MV duration, days (SD)†7.2 (10.5)5.5 (6.7)4.7 (4.5)
Balancing measures
 No of MV patients per month (SD)‡16 (3.6)18 (5.8)15 (7.4)
 ICU case severity index (SD)‡1.09 (0.35)1.16 (0.17)1.10 (0.24)
 Ventilator utilisation ratio§0.230.240.17
Process measures
 % Order for SAT¶30%67%68%
 % Order for SBT¶51%73%81%
  • *Negative binomial regression comparison of period 1 with baseline and period 2 with baseline non-significant (p=0.468 and p=0.105, respectively, for VAE rate per 1000 ventilator days; p=0.506 and 0.059, respectively, for VAE rate per 100 ventilated patients).

  • †ANOVA F-test of baseline, period 1 and period 2 significant (p=0.017), post-test pairwise comparison of period 2 with baseline significant (p=0.049).

  • ‡ANOVA F-test of baseline, period 1 and period 2 non-significant (p=0.647 for MV patients; p=0.894 for ICU case severity index).

  • §Pearson χ2 test of baseline, period 1 and period 2 significant (p<0.001), post-test pairwise comparison of period 2 with baseline significant (p<0.001) and comparison of period 2 with period 1 significant (p<0.001).

  • ¶Pearson χ2 test of baseline, period 1 and period 2 significant (p<0.001), post-test pairwise comparison of period 1 with baseline significant (p<0.001) and comparison of period 2 with baseline significant (p<0.001) (for SAT and SBT orders).

  • ICU, intensive care unit; MV, mechanical ventilation; SAT, spontaneous awakening trial; SBT, spontaneous breathing trial.