Table 1

Patient characteristics and outcomes preintervention and postintervention

Preintervention
(first cycle)
Postintervention
(second cycle)
ORP value
Patient characteristics and vital signs
N7469
Age72.0 (56.0–77.0)73.5 (61.8–80.0)0.16
HR99.5 (90.8–110.3)98.0 (87.5–107.0)0.31
HR >9057 (77.0)49 (71.0)0.41
Temperature38.3 (38.0–38.6)38.3 (38.1–38.7)0.21
Temperature>38°C56 (75.7)58 (84.1)0.21
WCC13.95 (10.9–18.2)12.7 (10.0–15.7)0.06
WCC >1252 (70.3)36 (52.2)0.03
RR18.0 (16.0–20.0)18.0 (16.0–21.0)0.92
RR >2015 (20.3)19 (27.5)0.31
SBP <100760.87
SEWS (25th, 75th)2.0 (1.0–3.0)2.0 (1.0–3.0)0.92
SEWS >414 (18.9)14 (20.3)0.84
FY1 first reviewer40 (54.1)45 (65.2)0.17
Postoperative sepsis38 (51.4)44 (63.8)0.13
Non-elective surgery5 (11.6)6 (13.0)0.92
Out of hours40 (54.1)36 (52.2)0.75
Outcome measures
Median TTAbx3.6 (1.9–6.9)1.7 (1.0–3.8)<0.001
Abx <1 hour2 (2.7)19 (27.5)13.68 (3.05–61.37)<0.001
Abx >3 hours45 (57.0)23 (33.3)0.322 (0.16–0.64)0.001
Had lactate12 (16.2)28 (40.6)3.53 (1.61–7.72)0.001
Had blood cultures43 (58.1)53 (76.8)2.39 (1.16–4.93)0.02
Urine output measured56 (75.7)52 (75.4)0.980.97
IVF given41 (55.4)43 (62.3)1.33 (0.68–2.60)0.4
  • SEWS, trigger for medical review at time of first cycle=4.

  • FY1, foundation year 1; HR, heart rate;IVF, intravenous fluid; RR, respiratory rate;SBP, systolic blood pressure;SEWS, Scottish Early Warning Score;TTABx, time to antibiotics from first SIRS;WCC, white cell count.