[HTML][HTML] Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases
J Lloyd-Price, C Arze, AN Ananthakrishnan… - Nature, 2019 - nature.com
Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …
Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry
MB Heyman, BS Kirschner, BD Gold, G Ferry… - The Journal of …, 2005 - Elsevier
OBJECTIVE: To determine the characteristics of inflammatory bowel disease (IBD) in young
patients. STUDY DESIGN: Uniform data were collected from a cohort of patients with IBD …
patients. STUDY DESIGN: Uniform data were collected from a cohort of patients with IBD …
Intraepithelial eosinophils: a new diagnostic criterion for reflux esophagitis
HS Winter, JL Madara, RJ Stafford, RJ Grand… - Gastroenterology, 1982 - Elsevier
Intraepithelial eosinophils in esophageal biopsy specimens were noted to be an indicator of
prolonged acid reflux. The presence of even a few intraepithelial eosinophils correlated with …
prolonged acid reflux. The presence of even a few intraepithelial eosinophils correlated with …
Induction and maintenance therapy with infliximab for children with moderate to severe ulcerative colitis
J Hyams, L Damaraju, M Blank, J Johanns… - Clinical …, 2012 - Elsevier
BACKGROUND & AIMS: We evaluated the efficacy and safety of infliximab for inducing and
maintaining benefit in children with moderately to severely active ulcerative colitis (UC) …
maintaining benefit in children with moderately to severely active ulcerative colitis (UC) …
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility
Genome-wide association studies (GWASs) have identified hundreds of loci associated with
Crohn's disease (CD). However, as with all complex diseases, robust identification of the …
Crohn's disease (CD). However, as with all complex diseases, robust identification of the …
Development of extraintestinal manifestations in pediatric patients with inflammatory bowel disease
FA Jose, EA Garnett, E Vittinghoff… - Inflammatory bowel …, 2009 - academic.oup.com
Background Extraintestinal manifestations (EIMs) in pediatric patients with inflammatory
bowel disease (IBD) are poorly characterized. We examined the prevalence of EIMs at …
bowel disease (IBD) are poorly characterized. We examined the prevalence of EIMs at …
MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis
G Koukos, C Polytarchou, JL Kaplan… - Gastroenterology, 2013 - Elsevier
Background & Aims Altered levels and functions of microRNAs (miRs) have been associated
with inflammatory bowel diseases (IBDs), although little is known about their roles in …
with inflammatory bowel diseases (IBDs), although little is known about their roles in …
Risk factors for initial surgery in pediatric patients with Crohn's disease
N Gupta, SA Cohen, AG Bostrom, BS Kirschner… - Gastroenterology, 2006 - Elsevier
Background & Aims: The cumulative incidence of surgery ranges from 40%–70% at 10 years
from the time of diagnosis of Crohn's disease in adults. We retrospectively determined the …
from the time of diagnosis of Crohn's disease in adults. We retrospectively determined the …
Risk of early surgery for Crohn's disease: implications for early treatment strategies
OBJECTIVES: In this study we aimed to define the rate of early surgery for Crohn's disease
and to identify risk factors associated with early surgery as a basis for subsequent studies of …
and to identify risk factors associated with early surgery as a basis for subsequent studies of …
[HTML][HTML] DGAT1 mutation is linked to a congenital diarrheal disorder
JT Haas, HS Winter, E Lim, A Kirby… - The Journal of …, 2012 - Am Soc Clin Investig
Congenital diarrheal disorders (CDDs) are a collection of rare, heterogeneous
enteropathies with early onset and often severe outcomes. Here, we report a family of …
enteropathies with early onset and often severe outcomes. Here, we report a family of …